With a so-called cryo plasma-FIB (Plasma Focused Ion Beam) scanning electron microscope with nanomanipulator, Goethe University in Frankfurt (Germany) is expanding its research infrastructure with a ...

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

Over the past two decades, correlative light and electron microscopies (CLEM), have become crucial for deciphering biological complexities across scales. A pivotal aspect of this workflow is the ...

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open questions in cell biology. Using cryo-electron microscopy (cryo-EM), Leonid ...

In Nijmegen, Netherlands, researchers have installed the world's first microscope capable of live imaging of biological processes in such detail that moving protein complexes are visible. This new ...

Cellular cryo-ET is a powerful method to study the structure and interactome of macromolecules directly in the cell. To access the cell interior at near-native conditions, cells are vitrified on grids ...

Berkeley Lab and UC Berkeley physicists' new technique offers detailed images of the small molecules and cell structures that ...

Advanced light microscopy techniques are giving scientists a new understanding of human biology and what goes wrong in diseases Katarina Zimmer, Knowable Magazine Key takeaways: Super-resolution ...

(a) A scanning electron microscope (SEM) image of the nanoneedle probe used for the measurements. (b) Elasticity map of a 1 µm × 1 µm area on the nuclear surface, showing the change in elasticity ...

Using a tiny, spherical glass lens sandwiched between two brass plates, the 17th-century Dutch microscopist Antonie van Leeuwenhoek was the first to officially describe red blood cells and sperm cells ...