C&EN

How growth-coupled selection could rebuild metabolism

Arren Bar-Even drove a new way to engineer metabolism; his former collaborators and students are continuing the work ...
Nature

MicroMap: a network visualisation resource for human microbiome metabolism

Human microbiome metabolism is intricately linked to health and disease 1. Investigating the relationships between intrinsic (e.g., genetics) and extrinsic (e.g., nutrition) contributing factors ...
Medical Xpress

Reprogramming the metabolic pathways of immune cells to improve cancer treatment

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...
Nature

A personalized metabolic modelling approach through integrated analysis of RNA-Seq-based genomic variants and gene expression levels in Alzheimer’s disease

Generating condition-specific metabolic models by mapping gene expression data to genome-scale metabolic models (GEMs) is a routine approach to elucidate disease mechanisms from a metabolic ...
ascopubs.org

Microbial metabolic pathways to abrogate immunotherapy toxicity and promote anti-tumor response in metastatic renal cell cancer.

Clinical outcomes of a prospective multicenter study evaluating a combined circulating tumor DNA (ctDNA) and RNA (ctRNA) liquid biopsy assay in metastatic non-small cell lung cancer (NSCLC). This is ...
Medical Xpress

Inflammation and metabolic stress combine to drive a new cell death pathway—mitoxyperilysis

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur together. A study from St. Jude Children's Research Hospital, published in Cell, ...